Salivary C-terminal Telopeptide Levels in Patients with Medication-related Osteonecrosis of the Jaw

Objectives: To examine the level of saliva total protein and C-terminal telopeptide of type 1 collagen (CTX) in patients who receiving anti-resorptive drugs.

Patients and methods: A study compared in 3 groups (n=8): MRONJ patients, patients receiving anti-resorptive drugs without MRONJ development and participants without drug use. Unstimulated saliva samples were collected and analyzed levels of saliva total protein and CTX. One-way ANOVA was used for statistical analysis with p-value < 0.05.

Results: We found the lowest saliva CTX levels in MRONJ patients. A statistically significant reduction of the saliva CTX levels was found in MRONJ patients compared with at-risk patients (p=0.011).

Conclusion: CTX a bone resorption biomarker, can be detected in saliva. The level of saliva CTX in patients with MRONJ may decrease from the effect of anti-resorptive drugs. This suggests that saliva CTX might be used to predict the risk of MRONJ development in patients who are taking anti-resorptive drugs.

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Wongla A, Buranaphatthana W, Tachasuttirut K. Salivary C-terminal Telopeptide Levels in Patients with Medication-related Osteonecrosis of the Jaw: Original articles. CM Dent J [Internet]. 2020 Jan 01 [cited 2024 Jul 23];42(1):173-183. Available from:

Wongla, A., Buranaphatthana, W. & Tachasuttirut, K. (2020). Salivary C-terminal Telopeptide Levels in Patients with Medication-related Osteonecrosis of the Jaw. CM Dent J, 42(1), 173-183. Retrieved from:

Wongla, A., Buranaphatthana Worakanya and Tachasuttirut Kathawut. 2020. "Salivary C-terminal Telopeptide Levels in Patients with Medication-related Osteonecrosis of the Jaw." CM Dent J, 42(1), 173-183.

Wongla, A. et al. 2020. 'Salivary C-terminal Telopeptide Levels in Patients with Medication-related Osteonecrosis of the Jaw', CM Dent J, 42(1), 173-183. Retrieved from

Wongla, A., Buranaphatthana, W. and Tachasuttirut, K. "Salivary C-terminal Telopeptide Levels in Patients with Medication-related Osteonecrosis of the Jaw", CM Dent J, vol.42, no. 1, pp. 173-183, Jan. 2020.

Wongla Atchara, Buranaphatthana Worakanya, Tachasuttirut Kathawut "Salivary C-terminal Telopeptide Levels in Patients with Medication-related Osteonecrosis of the Jaw." CM Dent J, vol.42, no. 1, Jan. 2020, pp. 173-183,