Salivary C-terminal Telopeptide Levels in Patients with Medication-related Osteonecrosis of the Jaw
Objectives: To examine the level of saliva total protein and C-terminal telopeptide of type 1 collagen (CTX) in patients who receiving anti-resorptive drugs.
Patients and methods: A study compared in 3 groups (n=8): MRONJ patients, patients receiving anti-resorptive drugs without MRONJ development and participants without drug use. Unstimulated saliva samples were collected and analyzed levels of saliva total protein and CTX. One-way ANOVA was used for statistical analysis with p-value < 0.05.
Results: We found the lowest saliva CTX levels in MRONJ patients. A statistically significant reduction of the saliva CTX levels was found in MRONJ patients compared with at-risk patients (p=0.011).
Conclusion: CTX a bone resorption biomarker, can be detected in saliva. The level of saliva CTX in patients with MRONJ may decrease from the effect of anti-resorptive drugs. This suggests that saliva CTX might be used to predict the risk of MRONJ development in patients who are taking anti-resorptive drugs.
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