Kimura disease of Submandibular Lymph Node: A Case Report and Review of Literature

Kimura Disease (KD) is a rare benign chronic inflammatory disorder, believed to be resulted from an immune-mediated hypersensitivity reaction to unknown agents. Clinically, it usually manifests as painless subcutaneous nodules in the head or neck region, accompanied by regional lymphadenopathy or salivary gland involvement. Laboratory finding shows peripheral blood and tissue eosinophilia, together with markedly elevated serum immunoglobulin E (IgE) levels. KD is often confused with angiolymphoid hyperplasia with eosinophilia (ALHE), another separate entity with overlapping histopathologic features. A case of KD in a 30-year-old Thai male with right submandibular swelling was presented together with a brief review of literature.

Kimm HT, Szeto C. Eosinophilic hyperplastic lymphogranuloma, comparison with Mikulicz’s disease. Chin Med J 1937; 23: 699-700.


Kimura T, Yoshimura S, Ishikawa E. Unusual granulation combined with hyperplastic changes of lymphatic tissue [in Japanese]. Trans Soc Pathol Jpn. 1948; 37: 179–180.

Sud K, Saha T, Das A, et al. Kimura’s disease and minimal‑change nephrotic syndrome. Nephrol Dial Transplant 1996; 11:1349-1351.

Miya T, Yamaki M, Furuya T, Watanabe T, Yokoe H, Tazawa H. A case of eosinophilic granuloma of the soft tissue (Kimura’s disease) arising in the palate. Jpn J Oral Maxillofac Surg 1999; 45: 527–529.

Ishii M. Kimura’s disease: a review of 429 cases and 4 new cases. Oto- RhinoLaryngology (Tokyo) 1982; 25: 407–416.

Terakado N, Sasaki A, Takebayashi T, Matsumura T, Kojou T: A case of Kimura’s disease of the hard palate. Int J Oral Maxillofac Surg 2002; 31: 222–224.

Meningaud JP, Pitak-Arnnop P, Fouret P, Bertrand JC. Kimura’s disease of the parotid region: Report of 2 cases and review of the literature. J Oral Maxillofac Surg 2007; 65: 134-140.

Seregard S. Angiolymphoid hyperplasia with eosinophilia should not be confused with Kimura’s disease. Acta Ophthalmol Scand 2001; 79: 91-93.

Rosai J, Gold J, Landy R. The histiocytoid hemangiomas. A unifying concept embracing several previously described entities of skin, soft tissue, large vessels, bone, and heart. Hum Pathol 1979; 10: 707 730.

Sun QF, Xu DZ, Pan SH, et al. Kimura disease: review of the literature. Intern Med J 2008; 38: 668–672.

Chong WS, Thomas A, Goh CL. Kimura’s disease and angiolymphoid hyperplasia with eosinophilia: Two disease entities in the same patient: Case report and review of the literature. Int J Dermatol 2006; 45: 139-145.

Tseng CF, Lin HC, Huang SC, Su CY. Kimura's disease presenting as bilateral parotid masses. Eur Arch Otorhinolaryngol 2005; 262: 8–10.

Rajpoot DK, Pahl M, Clark J. Nephrotic syndrome associated with Kimura disease. Pediatr Nephrol 2000; 14(6): 486-488.

Dik VK, van der Wiel BA, Vasmel WL. Kimura’s disease of the parotid glands and multiple cervical lymph nodes. Neth J Med 2010; 68: 1757.

Park SW, Kim JH, Sung KJ, Lee JH, Park IS. Kimura Disease: CT and MR Imaging Findings. AJNR Am J Neuroradiol 2012; 33: 784–788.

Googe PB, Harris NL, Mihm MC, Jr. Kimura’s disease and angiolymphoid hyperplasia with eosinophilia: two distinct histopathological entities. J Cutan Pathol 1987; 14: 263–271.

Rosai J. Angiolymphoid hyperplasia with eosinophilia of the skin. Its nosological position in the spectrum of histiocytoid hemangioma. Am J Dermatopathol 1982; 4: 175–184.

Chun SI, Ji HG. Kimura’s disease and angiolymphoid hyperplasia with eosinophilia: clinical and histopathologic differences. J Am Acad Dermatol 1992; 27: 954–958.

Kristina B, Sabrina R, Axel T, Eva-Bettina B, Matthias G, Andreas K. Angiolymphoid hyperplasia with eosinophilia and Kimura’s disease – a clinical and histopathological comparison. J German Soc Dermatol 2014; 224-228.

Goecmen H, Oguz H, Astarci M, Samim E. Kimura's disease: case report and brief review of the literature. J Otolaryngol 2006; 35(5): 358-360

Hui PK, Chan JK, Ng CS, Kung IT, Gwi E. Lymphadenopathy of Kimura’s disease. Am J Surg Pathol 1989; 13: 177-186.

Briggs PL. Kimura disease is not angiolymphoid hyperplasia with eosinophilia: clinical and pathological correlation with literature review and definition of diagnostic criteria. An Bras Dermatol 2006; (2): 167-173.

Zhang R, Ban XH, Mo YX, et al. Kimura's disease: the CT and MRI characteristics in fifteen cases. Eur J Radiol 2011; 80(2): 489-497.

Chow LT, Yuen RW, Tsui WM, Ma TK, Chow WH, Chan SK. Cytologic features of Kimura's disease in fine-needle aspirates. A study of eight cases. Am J Clin Pathol 1994; 102(3): 316-321.

Motoi M, Wahid S, Horie Y, Akagi T. Kimura’s disease: clinical, histological, and immunohistochemical studies. Acta Med Okayama 1992; 46: 449–455.

Armstrong WB, Allison G, Pena F, Kim JK. Kimura’s disease: Two case reports and a literature review. Ann Otol Rhinol Laryngol 1998; 107: 1066-1071.

Hongcharu W, Baldassano M, Taylor CR. Kimura’s disease with oral ulcers: response to pentoxifylline. J Am Acad Dermatol 2000; 43: 905–907.

Day TA, Abreo F, Hoajsoe DK, Aarstad RF, Stucker FJ. Treatment of Kimura’s disease: a therapeutic enigma. Otolaryngol Head Neck Surg.1995; 112: 333–337.

Olsen TG, Helwig EB. Angiolymphoid hyperplasia with eosinophilia. A clinicpathologic study of 116 patients. J Am Acad Dermatol 1985; 12: 781–796.

Kim GE, Kim WC, Yang WI, et al. Radiation treatment in patients with recurrent Kimura’s disease. Int J Radiat Oncol Biol Phys 1997; 38: 607–612.

Massa MC, Fretzin DF, Chowdhury L, Sweet DL. Angiolymphoid hyperplasia demonstrating extensive skin and mucosal lesions controlled with vinblastine therapy. J Am Acad Dermatol 1984; 11: 333-339.

Da-long S, Wei R, Bing G, Yun-yan Z, Xiang-Zhen L, Xin L. Tacrolimus on Kimura’s disease: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol 2014; 117: e74-e78.

Rattana-arpha P, Phattarataratip E. Kimura disease of Submandibular Lymph Node: A Case Report and Review of Literature: A case reports/series. CM Dent J [Internet]. 2019 May 01 [cited 2024 May 21];40(2):139-146. Available from: https://www.dent.cmu.ac.th/cmdj/frontend/web/?r=site/viewarticle&id=93

Rattana-arpha, P. & Phattarataratip, E. (2019). Kimura disease of Submandibular Lymph Node: A Case Report and Review of Literature. CM Dent J, 40(2), 139-146. Retrieved from: https://www.dent.cmu.ac.th/cmdj/frontend/web/?r=site/viewarticle&id=93

Rattana-arpha, P., and Phattarataratip Ekarat. 2019. "Kimura disease of Submandibular Lymph Node: A Case Report and Review of Literature." CM Dent J, 40(2), 139-146. https://www.dent.cmu.ac.th/cmdj/frontend/web/?r=site/viewarticle&id=93

Rattana-arpha, P. et al. 2019. 'Kimura disease of Submandibular Lymph Node: A Case Report and Review of Literature', CM Dent J, 40(2), 139-146. Retrieved from https://www.dent.cmu.ac.th/cmdj/frontend/web/?r=site/viewarticle&id=93

Rattana-arpha, P. and Phattarataratip, E. "Kimura disease of Submandibular Lymph Node: A Case Report and Review of Literature", CM Dent J, vol.40, no. 2, pp. 139-146, May. 2019.

Rattana-arpha Pornpop, Phattarataratip Ekarat "Kimura disease of Submandibular Lymph Node: A Case Report and Review of Literature." CM Dent J, vol.40, no. 2, May. 2019, pp. 139-146, https://www.dent.cmu.ac.th/cmdj/frontend/web/?r=site/viewarticle&id=93