Oral Potentially Malignant Disorders: Clinical Manifestations and Malignant Transformation
Oral potentially malignant disorders (OPMDs)” are diseases or conditions that carry risks of oral cancer consisting of leukoplakia, erythroplakia, palatal lesions in reverse smoker, oral submucous fibrosis, lichen planus, discoid lupus erythematosus, actinic cheilitis and inherited cancer syndromes. Each of these OPMDs has different prevalence, clinical manifestations and malignant potential. However, the clinical presentations of some OPMDs may resemble those soft tissue lesions which do not carry risk of oral cancer. Therefore, they become challenges for dentists to make appropriate diagnosis.
This literature review will mainly focus on the clinical manifestations and malignant transformation of OPMDs including leukoplakia, erythroplakia, palatal lesions in reverse smoker, oral submucous fibrosis, lichen planus, discoid lupus erythematosus and actinic cheilitis.
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