A Delayed Onset Cyst-like Lesion at the Lip after Hyaluronic Acid Filler Injection: A Case Report

Atapol Yongvikul, Manop Khanijou, Natthamet Wongsirichat, Thongnard Kumchai

Published Online: May 29, 2025 DOI 10.12982/OSR.2025.053

Nowadays, lip augmentation has become a key component in addressing cosmetic concerns. In particular, hyaluronic acid (HA) fillers are increasingly used for this minimally invasive procedure. Generally, this procedure is well-tolerated, and major adverse events are rare. However, some delayed complications can occur following HA filler injection. Here, we report a case of a HA-related complication in a 45-year-old female patient, affecting the lower lip. Four weeks after the HA filler application, without any immediate adverse effects, a painless, well-defined border nodule occurred in the wet lip area. This cyst-like lesion was surgically identified and successfully treated with surgical excision. Clinicians should be aware that a case manifesting as a well-defined lip nodule suggests salivary gland cysts, soft tissue tumors and cysts, as well as filler-related nodules. This delayed presentation of HA-related nodule in the lower lip poses unique diagnostic and management challenges.

filler filler complication hyaluronic acid lip mucocele
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Yongvikul A, Khanijou M, Wongsirichat N, Kumchai T. A Delayed Onset Cyst-like Lesion at the Lip after Hyaluronic Acid Filler Injection: A Case Report: A case reports/series. Oral Sci Rep [Internet]. 2025 May 29 [cited 2025 May 31];46(2):120-124. Available from: https://www.dent.cmu.ac.th/cmdj/frontend/web/?r=site/viewarticle&id=508

Yongvikul, A., Khanijou, M., Wongsirichat, N. & Kumchai, T. (2025). A Delayed Onset Cyst-like Lesion at the Lip after Hyaluronic Acid Filler Injection: A Case Report. Oral Sci Rep, 46(2), 120-124. Retrieved from: https://www.dent.cmu.ac.th/cmdj/frontend/web/?r=site/viewarticle&id=508

Yongvikul, A., Manop Khanijou,Natthamet Wongsirichat and Thongnard Kumchai. 2025. "A Delayed Onset Cyst-like Lesion at the Lip after Hyaluronic Acid Filler Injection: A Case Report." Oral Sci Rep, 46(2), 120-124. https://www.dent.cmu.ac.th/cmdj/frontend/web/?r=site/viewarticle&id=508

Yongvikul, A. et al. 2025. 'A Delayed Onset Cyst-like Lesion at the Lip after Hyaluronic Acid Filler Injection: A Case Report', Oral Sci Rep, 46(2), 120-124. Retrieved from https://www.dent.cmu.ac.th/cmdj/frontend/web/?r=site/viewarticle&id=508

Yongvikul, A., Khanijou, M., Wongsirichat, N. and Kumchai, T. "A Delayed Onset Cyst-like Lesion at the Lip after Hyaluronic Acid Filler Injection: A Case Report", Oral Sci Rep, vol.46, no. 2, pp. 120-124, May. 2025.

Yongvikul, A., Khanijou, M., Wongsirichat, N., et al. "A Delayed Onset Cyst-like Lesion at the Lip after Hyaluronic Acid Filler Injection: A Case Report." Oral Sci Rep, vol.46, no. 2, May. 2025, pp. 120-124, https://www.dent.cmu.ac.th/cmdj/frontend/web/?r=site/viewarticle&id=508